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This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid (AMA). Alternative splicing results in multiple transcript variants.
AA408458; AGS; AI325141; BA46; breast epithelial antigen BA46; EDIL1; EGF/factor VIII; HMFG; hP47; HsT19888; lactadherin; Lactadherin short form; Medin; Mfge8; MFG-E8; MFGM; MFGME8; MFGMP-E8; milk fat globule glycoprotein; milk fat globule membrane; milk fat globule membrane protein; Milk fat globule-EGF factor 8; milk fat globule-EGF factor 8 protein; MP47; O-acetyl disialoganglioside synthase; O-acetyl GD3 ganglioside synthase; O-acetyltransferase milk fat globule membrane protein; O-acetyltransferase Milk fat glolbule membrane protein; OAcGD3S; P47; SED1; SPAG10; sperm associated antigen 10; sperm surface protein hP47; sperm surface protein SP47
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